Oxidative Stress Induces Disruption of the Axon Initial Segment
نویسندگان
چکیده
منابع مشابه
Oxidative Stress Induces Disruption of the Axon Initial Segment
The axon initial segment (AIS), the domain responsible for action potential initiation and maintenance of neuronal polarity, is targeted for disruption in a variety of central nervous system pathological insults. Previous work in our laboratory implicates oxidative stress as a potential mediator of structural AIS alterations in two separate mouse models of central nervous system inflammation, a...
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ii Acknowledgement I want to first thank my advisor and mentor, Dr. Jeffrey Dupree, for his support, guidance and patience over the last two years. Under his instruction I learned what it means to think critically about my work and perform hypothesis driven science. I will always be grateful to him for teaching me what it means to perform good science, and I hope to continue developing as both ...
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Axon hillocks and initial segments have been recognized and studied in electron micrographs of a wide variety of neurons. In all multipolar neurons the fine structure of the initial segment has the same pattern, whether or not the axon is ensheathed in myelin. The internal structure of the initial segment is characterized by three special features: (a) a dense layer of finely granular material ...
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The axon initial segment is a unique neuronal subregion involved in the initiation of action potentials and in the control of axonal identity. Recent work has helped our understanding of how this specialised structure develops, not least in identifying possible mechanisms leading to the localisation of the AIS's master organiser protein, ankyrin-G. The most exciting current work, however, focus...
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The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the AIS unique electrical properties. Here we review recent data on the physiology of the AIS. These data indicate that the role of the AIS is far ri...
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ژورنال
عنوان ژورنال: ASN Neuro
سال: 2017
ISSN: 1759-0914,1759-0914
DOI: 10.1177/1759091417745426